| 產(chǎn)品編號(hào) | bs-0688R-Gold |
| 英文名稱 | Rabbit Anti-Nm23/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的腫瘤轉(zhuǎn)移抑制基因抗體 |
| 別 名 | nucleoside dIPhosphatase kinase A; AWD; AWD, drosophila, homolog of; GAAD; Granzyme A activated DNase; GZMA activated DNase; Metastasis inhibition factor nm23; NB; NBS; NDK A; NDP kinase A; KDKA; NDPK-A; NDPKA; NDPKB; NM23 H1; NM23 long variant, included; NM23-H1; NM23-M1; NM23B; NM23H1B; NM23H1B, included; NME1; NME1-NME2 spliced read-through transcript, included; NME2; Non metastatic cells 1 protein; Non-metastatic cells 1, protein (NM23A) expressed in; Nonmetastatic cells 1, protein expressed in; Nonmetastatic protein 23; Nonmetastatic protein 23, homolog 1; Nucleoside diphosphate kinase A; Tumor metastatic process associated protein; Tumor metastatic process-associated protein. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 腫瘤 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 性 狀 | Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Nm23 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. Subunit: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with SET and PRUNE. Subcellular Location: Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA. Tissue Specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. Similarity: Belongs to the NDK family. Database links: Entrez Gene: 4830 Human Entrez Gene: 18102 Mouse Omim: 156490 Human SwissProt: P15531 Human SwissProt: P15532 Mouse Unigene: 463456 Human Unigene: 439702 Mouse Unigene: 6236 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. nm23是一種轉(zhuǎn)移抑制基因，主要用于胃腸道癌、乳腺癌、肺癌的多種惡性腫瘤的研究。大多數(shù)研究結(jié)果表明，nm23陽(yáng)性表達(dá)與腫瘤轉(zhuǎn)移負(fù)相關(guān)，與病人的預(yù)后呈正相關(guān)，但也有人研究報(bào)道與轉(zhuǎn)移或預(yù)后無(wú)相關(guān)性，說(shuō)明其結(jié)論仍有爭(zhēng)議。 |
