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Rabbit Anti-MMP11/APC Conjugated antibody (bs-1853R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1853R-APC
英文名稱 Rabbit Anti-MMP11/APC Conjugated antibody
中文名稱 APC標記的基質(zhì)金屬蛋白酶11抗體
別    名 matrix metalloproteinase 11; Stromelysin-3; SL-3; Matrix metalloproteinase-11; MMP11; MMP 11; MMP-11; SL 3; SL3; ST 3; ST3; STMY 3; STMY3; Stromelysin 3; Stromelysin 3 precursor; Stromelysin III; Stromelysin3; StromelysinIII. MMP11_HUMAN; stromelysin-3 preproprotein.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43/51kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMP11
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008].

Function:
May play an important role in the progression of epithelial malignancies.

Subunit:
Secreted, extracellular space, extracellular matrix (Probable).

Subcellular Location:
Secreted, extracellular space, extracellular matrix (Probable).

Tissue Specificity:
Specifically expressed in stromal cells of breast carcinomas.

Post-translational modifications:
The precursor is cleaved by a furin endopeptidase.

Similarity:
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.

Database links:

Entrez Gene: 4320 Human

Entrez Gene: 17385 Mouse

Entrez Gene: 25481 Rat

Omim: 185261 Human

SwissProt: P24347 Human

SwissProt: Q02853 Mouse

SwissProt: Q499S5 Rat

Unigene: 143751 Human

Unigene: 4561 Mouse

Unigene: 11123 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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