| 產(chǎn)品編號(hào) | IHC0663H |
| 英文名稱 | Human CD59 Ready-To-Use IHC Kit |
| 中文名稱 | 人CD59即用型免疫組化試劑盒 |
| 別 名 | 16.3A5; 1F5; CD59; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20; CD59 glycoprotein |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). CD59 is the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 also associates with C5b-8 complex and counteracts appropriate formation of cytolytic pore within the plasma membrane. Further, CD59 is a low-affinity ligand of human CD2, causes T cell costimulation, and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. Mutations in this gene cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified. SWISS: P13987 Gene ID: 966 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Human placenta tissue slide using IHC0663H (Human CD59 Kit).
Immunohistochemical analysis of paraffin embedded Human lung cancer tissue slide using IHC0663H (Human CD59 Kit).
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