| 產(chǎn)品編號 | IHC0656M |
| 英文名稱 | Mouse CD8 alpha Ready-To-Use IHC Kit |
| 中文名稱 | 小鼠CD8即用型免疫組化試劑盒 |
| 別 名 | CD8; CD8A; CD8B; CD8B1; LEU2; LY3; LYT3; MAL; p32; P37; CD8 antigen; alpha polypeptide (p32); CD8a; CD8a antigen; CD8a molecule; CD8A_HUMAN; Leu2; Leu2 T lymphocyte antigen; OKT8 T cell antigen; T cell antigen Leu2; T cell co receptor; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; T8 T cell antigen |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
CD8, also known as cluster of differentiation 8, is a type I transmembrane glycoprotein of the immunoglobulin family that plays a crucial role in T cell differentiation, activation, and signal transduction. It is expressed as either a heterodimer (CD8 alpha beta) or a homodimer (CD8 alpha alpha). The CD8 alpha beta form is predominantly found on the majority of thymocytes and a subpopulation of mature alpha beta TCR T cells, while the CD8 alpha alpha form is expressed on gamma delta TCR T cells, a subset of intestinal intraepithelial lymphocytes (IELs), and dendritic cells. CD8 functions as a co-receptor for major histocompatibility complex class I (MHC-I) molecules, working alongside the T cell receptor (TCR). The CD8 alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes, and dendritic cells as disulfide-linked homodimers of CD8 alpha. Upon ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), CD8 recruits lymphocyte-specific protein tyrosine kinase (Lck), leading to lymphokine production, increased motility, and activation of cytotoxic T lymphocytes (CTLs). Activated CTLs are vital for clearing pathogens and tumor cells. The differentiation of naive CD8+ T cells into CTLs is strongly enhanced by cytokines such as IL-2, IL-12, and TGF-beta1. Through its interactions with MHC-I and association with protein tyrosine kinase p56lck, CD8 plays a significant role in T cell development and the activation of mature T cells. SWISS: P01732 Gene ID: 925 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Mouse thymus tissue slide using IHC0656M (Mouse CD8 alpha Kit).
Immunohistochemical analysis of paraffin embedded Mouse small intestine tissue slide using IHC0656M (Mouse CD8 alpha Kit).
Immunohistochemical analysis of paraffin embedded Mouse lymph tissue slide using IHC0656M (Mouse CD8 alpha Kit).
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