| 產(chǎn)品編號(hào) | IHC0648R |
| 英文名稱 | Rat Collagen I Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠I型膠原蛋白/膠原蛋白1/1型膠原蛋白/I型膠原a1即用型免疫組化試劑盒 |
| 別 名 | AA960264; AI325291; Col1a-1; Col1a-2; COL1A1; COL1A2; Cola-1; Cola-2; Cola1; Cola2; COLIA1; EDSC; I79_010913; Mov-13; Mov13; OI1; OI2; OI3; OI4; oim; Alpha 1 type I collagen; Collagen alpha 1(I) chain; collagen type I; alpha 1 |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified. SWISS: P02452 Gene ID: 1277 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Rat lung tissue slide using IHC0648R (Rat Collagen I Kit).
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