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Human ZO-1 Ready-To-Use IHC Kit (IHC0641H)  
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50T/3200.00元
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產(chǎn)品編號 IHC0641H
英文名稱 Human ZO-1 Ready-To-Use IHC Kit
中文名稱 人胞質(zhì)緊密粘連蛋白1/閉鎖小帶蛋白1即用型免疫組化試劑盒
別    名 TJP1; ZO-1; ZO1; Tight junction protein 1; Tight junction protein ZO 1; ZO 1; Zona occludens protein 1; Zonula occludens protein 1  
適用樣品基質(zhì) FFPE tissue
保存條件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
產(chǎn)品介紹 ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.

SWISS:
Q07157

Gene ID:
7082

產(chǎn)品圖片
Immunohistochemical analysis of paraffin embedded Human stomach tissue slide using IHC0641H (Human ZO-1 Kit).
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