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Rat PMCA1 Ready-To-Use IHC Kit (IHC0636R)  
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產品編號 IHC0636R
英文名稱 Rat PMCA1 Ready-To-Use IHC Kit
中文名稱 大鼠細胞膜鈣ATP酶1即用型免疫組化試劑盒
別    名 2810442I22Rik; ATP2B1; E130111D10Rik; PMCA1; Pmca1a; Pmca1b; Pmca1c; PMCA1kb  
適用樣品基質 FFPE tissue
保存條件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
產品介紹 The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/potassium pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.

SWISS:
P20020

Gene ID:
490

產品圖片
Immunohistochemical analysis of paraffin embedded Rat stomach tissue slide using IHC0636R (Rat PMCA1 Kit).
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