| 產(chǎn)品編號(hào) | IHC0607H |
| 英文名稱 | Human CD63 Ready-To-Use IHC Kit |
| 中文名稱 | 人黑色素瘤相關(guān)抗原即用型免疫組化試劑盒 |
| 別 名 | CD63; LAMP-3; ME491; MLA1; OMA81H; TSPAN30 |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
CD63, also known as LAMP-3, is a glycoprotein belonging to the tetraspanin family, primarily located in late endosomes, lysosomes, and secretory vesicles across various cell types. It is expressed intracellularly in resting platelets and basophils, but upon activation, CD63 translocates to the plasma membrane, making it a widely used marker for basophil activation. Unlike basophils, mast cells can expose CD63 without activation. CD63 is expressed on activated platelets, monocytes, macrophages, and granulocytes, as well as endothelial cells, fibroblasts, and smooth muscle cells. It interacts with integrins (such as VLA-3 and VLA-6) and TIMP-1, playing roles in mediating allergic responses, phagocytosis, and cell migration. Additionally, CD63 is involved in the regulation of H/K-ATPase trafficking and ROMK1 channels, and serves as a T-cell costimulation molecule. CD63 expression can be used to predict prognosis in early-stage carcinomas and is identical to the melanoma-associated antigen ME491 and the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome, highlighting its significance in both immune responses and disease processes. SWISS: P08962 Gene ID: 967 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Human spleen tissue slide using IHC0607H (Human CD63 Kit).
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Immunohistochemical analysis of paraffin embedded Human colon cancer tissue slide using IHC0607H (Human CD63 Kit).
Immunohistochemical analysis of paraffin embedded Human skeletal muscle tissue slide using IHC0607H (Human CD63 Kit).
Immunohistochemical analysis of paraffin embedded Human lung cancer tissue slide using IHC0607H (Human CD63 Kit).
Immunohistochemical analysis of paraffin embedded Human tonsil tissue slide using IHC0607H (Human CD63 Kit).
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