| 產(chǎn)品編號(hào) | IHC0396M |
| 英文名稱 | Mouse NALP3/CIAS1 Ready-To-Use IHC Kit |
| 中文名稱 | 小鼠細(xì)胞凋亡誘導(dǎo)蛋白NALP3即用型免疫組化試劑盒 |
| 別 名 | AGTAVPRL; AII; AII/AVP; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCAS1; FCU; Mmig1; MWS; NALP3; NLRP3; PYPAF1 |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. SWISS: Q96P20 Gene ID: 114548 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded mouse spleen tissue slide using IHC0396M (Mouse NALP3/CIAS1 IHC Kit).
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