| 產(chǎn)品編號(hào) | D60174 |
| 英文名稱 | NKL 22 |
| 中文名稱 | |
| 別 名 | PAOA; Histone Deacetylase Inhibitor IV |
| 克 隆 號(hào) | |
| CAS | 537034-15-4 |
| 理論分子量 | 325.4 kDa |
| 檢測分子量 | |
| 保存條件 | 2-8℃ |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
NKL 22 (compound 4b) is a potent and selective inhibitor of histone deacetylases (HDAC), with an IC50 of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 exhibits selectivity over HDAC2/4/5/7/8 (IC50≥1.59 μM). NKL 22 ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice |
