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PHGDH Rabbit pAb (bs-2970R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產(chǎn)品編號 bs-2970R
英文名稱 PHGDH Rabbit pAb
中文名稱 磷酸甘油酸脫氫酶抗體
別    名 3-phosphoglycerate dehydrogenase; D-3-phosphoglycerate dehydrogenase; EC 1.1.1.95; PDG; PGAD; PGD; PGDH; PGDH3; SERA; NLS; NLS1; 3PGDH; 3-PGDH; 3 PGDH; PHGDHD; HEL-S-113; SERA_HUMAN; EC:1.1.1.95; EC:1.1.1.399; EC:1.1.1.37; Malate dehydrogenase; 2-oxoglutarate reductase.  
研究領(lǐng)域 腫瘤  細胞生物  神經(jīng)生物學  信號轉(zhuǎn)導  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 56 kDa
檢測分子量
細胞定位 細胞漿 細胞外基質(zhì) 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PHGDH: 101-200/533 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]

Function:
Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.

Subunit:
Homotetramer

DISEASE:
Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) . It is characterized by congenital microcephaly, psychomotor retardation, and seizures.

Similarity:
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

SWISS:
O43175

Gene ID:
26227

Database links:

Entrez Gene: 26227 Human    
Entrez Gene: 236539 Mouse
Entrez Gene: 58835 Rat
SwissProt: O43175 Human
SwissProt: Q61753 Mouse

SwissProt: O08651 Rat




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