| 產(chǎn)品編號(hào) | bs-3689R |
| 英文名稱(chēng) | IL3RB Rabbit pAb |
| 中文名稱(chēng) | 粒細(xì)胞-巨噬細(xì)胞集落刺激因子受體β抗體 |
| 別 名 | IL3RB; IL-3RB; IL-3R beta; GM-CSFR beta; IL 3 receptor beta; IL-5RB; IL-5R beta; IL 5 receptor beta; GM-CSFrβ; GM-CSF receptor beta chain; GM-CSF/IL-3/IL-5 receptor common beta subunit; CSF2RB; IL3RB; IL5RB; GM CSF/IL 3/IL 5 receptor common beta chain; GM CSF/IL 3/IL 5 receptor common beta-chain; IL3RB; CD131; CDw131; Colony stimulating factor 2 receptor beta; Colony stimulating factor 2 receptor beta low affinity(granulocyte macrophage); Colony stimulating factor 2 receptor beta low-affinity(granulocyte macrophage); CSF2RB; Cytokine receptor common beta chain; Cytokine receptor common beta chain precursor(CDw131 antigen); Cytokine receptor common subunit beta; GM-CSF/IL-3/IL-5 receptor common beta subunit; IL3RB_HUMAN; IL5RB; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta(high affinity); Interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor beta(high affinity); stimulating factor 3 receptor, beta(high affinity). |
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Specific References (2) | bs-3689R has been referenced in 2 publications.
[IF=4.739] Zsiros V et al. Endocytosis of GM-CSF receptor β is essential for signal transduction regulating mesothelial-macrophage transition. Biochim Biophys Acta Mol Cell Res. 2019 Sep;1866(9):1450-1462. ICC&WB ; Rat.
[IF=2.452] Chou YH et al.Erythropoietin modulates macrophages but not post-ischemic acute kidney injury in mice.(2018)J Formos Med Assoc. Nov 7. pii: S0929-6646(18)30506-0. IHC ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 神經(jīng)生物學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 97 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GM-CSFR Beta: 441-540/897 <Cytoplasmic> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
GM-CSF Receptor Beta is the v subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Six transcript variants encoding five different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.
Function: High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with LYN. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:614370]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Post-translational modifications: May be phosphorylated by LYN. Similarity: Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 2 fibronectin type-III domains. SWISS: P32927 Gene ID: 1439 Database links: Entrez Gene: 1439 Human Entrez Gene: 12983 Mouse Entrez Gene: 12984 Mouse Omim: 138981 Human SwissProt: P32927 Human SwissProt: P26955 Mouse Unigene: 285401 Human Unigene: 592192 Human Unigene: 235324 Mouse |
