| 產(chǎn)品編號 | bs-2621R |
| 英文名稱 | IL21 Rabbit pAb |
| 中文名稱 | 白介素21抗體 |
| 別 名 | Interleukin 21; Interleukin21; IL 21; IL-21; Za11; Interleukin-21; interleukin-21 isoform; IL21_HUMAN. |
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Specific References (3) | bs-2621R has been referenced in 3 publications.
[IF=3.06] Guan, Li-juan, et al. "Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease." Cytokine 72.2 (2015): 160-165. IHC-P ; Human.
[IF=1.26] Gong, Qiaoqiao, et al. "Increased levels of CCR7 (lo) PD?1 (hi) CXCR5+ CD4+ T cells, and associated factors Bcl?6, CXCR5, IL?21 and IL?6 contribute to repeated implantation failure." Experimental and Therapeutic Medicine 14.6 (2017): 5931-5941. IHC-P ; Human.
[IF=1.26] Ma et al. Effect of follicular helper T cells on the pathogenesis of asthma. (2017) Exp.Ther.Me. 14:967-972 IHC-P ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Pig,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 18 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-21: 65-155/155 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Subcellular Location: Secreted. Tissue Specificity: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. Similarity: Belongs to the IL-15/IL-21 family. SWISS: Q9HBE4 Gene ID: 59067 Database links: Entrez Gene: 59067 Human Entrez Gene: 60505 Mouse Omim: 605384 Human SwissProt: Q9HBE4 Human SwissProt: Q9ES17 Mouse Unigene: 567559 Human Unigene: 157689 Mouse 白介素21是多效免疫調(diào)節(jié)活性的細(xì)胞因子,與其受體結(jié)合后可以調(diào)節(jié)并促進(jìn)B細(xì)胞、T細(xì)胞、NK細(xì)胞的增殖、分化并提高NK細(xì)胞殺傷活性。 |
